Yuchen He

A multi-tissue epigenomic atlas links the sheep non-coding genome to domestication and complex traits

SheepEpimap combines 516 histone CUT&Tag, ATAC-seq and RNA-seq datasets from 43 sheep tissues to annotate 2.93 million cis-regulatory elements and 145,407 allele-specific variants for trait interpretation.

A human lysosomal storage disorder toolkit for decoding proteome landscapes in cortical and dopaminergic-like induced neurons

The paper develops a human stem cell toolkit for studying lysosomal storage disorders by generating proteomic data from induced cortical and dopaminergic-like neurons.

Comparative analysis of naked mole-rat thermogenesis and its potential to maintain euthermia in response to cold

This study investigates the thermogenic potential of naked mole-rat brown adipose tissue and its ability to maintain body temperature in cold, finding that NMRs can initiate non-shivering thermogenesis but cannot sustain it due to heat loss and substrate limitations.

A Modular Platform for the Optogenetic Control of Small GTPase Activity in Living Cells Reveals Long-Range RhoA Signaling

Split-Small GTPase Reassembly as a Method to Control Cellular Signaling with User-Defined Inputs

This paper introduces a method to control small GTPase activity using split-GTPases and user-defined chemical inducers, enabling precise temporal regulation of cellular signaling.

Age-related increase in matrix stiffness downregulates α-Klotho in chondrocytes and induces cartilage degeneration

This study identifies age-related matrix stiffness as a driver of decreased α-Klotho in chondrocytes, leading to cartilage degeneration in mice and humans.