Fabrisia Ambrosio

The paper quantifies age-related decline in transcriptional information flow using information theory and single-cell RNA-seq data, finding reduced mutual information between transcription factors and target genes.

This study uses network inference to identify conserved and tissue-specific immune signaling changes in menopause-related fibrosis across multiple organs in mice.

The paper identifies Oncostatin M as a driver of inflammation in knee osteoarthritis using network-based cytokine inference and pharmacological manipulation in aged mice.

This paper evaluates how magnetic fields affect neural repair in vitro through systematic review, mathematical modeling, and meta-analysis, finding increased NPC proliferation and decreased astrocytic differentiation.

This study identifies Pgc-1α as a regulator of fat accumulation in aged skeletal muscle by analyzing transcriptomic responses to exercise and immobilization.

This study uses meta-analysis and multi-omics to identify inflammation, autophagy, and cellular senescence as key features of age-related KOA in mice, with unique molecular profiles distinct from post-traumatic OA.

This study identifies age-related matrix stiffness as a driver of decreased α-Klotho in chondrocytes, leading to cartilage degeneration in mice and humans.