Hirotaka Iijima

Decoding menopause-induced tissue fibrosis using pan-tissue network inference

This study uses network inference to identify conserved and tissue-specific immune signaling changes in menopause-related fibrosis across multiple organs in mice.

Systematic identification of exercise-induced anti-aging processes involving intron retention

This study identifies exercise-induced anti-aging processes in skeletal muscle by analyzing intron retention and its link to genomic instability and mitochondrial function.

Network-based cytokine inference implicates Oncostatin M as a driver for inflammation phenotype of knee osteoarthritis

The paper identifies Oncostatin M as a driver of inflammation in knee osteoarthritis using network-based cytokine inference and pharmacological manipulation in aged mice.

Pgc-1α is an exercise-responsive regulator of myosteatosis in older individuals

This study identifies Pgc-1α as a regulator of fat accumulation in aged skeletal muscle by analyzing transcriptomic responses to exercise and immobilization.

Meta-analysis and multi-omics to elucidate pathogenic mechanisms of age-related knee osteoarthritis

This study uses meta-analysis and multi-omics to identify inflammation, autophagy, and cellular senescence as key features of age-related KOA in mice, with unique molecular profiles distinct from post-traumatic OA.

Age-related increase in matrix stiffness downregulates α-Klotho in chondrocytes and induces cartilage degeneration

This study identifies age-related matrix stiffness as a driver of decreased α-Klotho in chondrocytes, leading to cartilage degeneration in mice and humans.