Anandsukeerthi Sandholu

This study identifies how SH3 domains activate PI3K by engaging in tertiary interactions with p85, revealing a mechanism for controlling activation through functional selection.

The paper introduces a benchmark and algorithm for designing proteins with conformational specificity, demonstrating success in redesigning MAP kinase ERK2 to maintain activity without phosphorylation.

The paper analyzes the structural and functional differences of Arabidopsis CDC48A compared to animal and fungal CDC48 systems, revealing unique cofactor interactions and evolutionary adaptations in plants.

This paper introduces P-NADs, a ubiquitin-independent protein degradation method using PUX-adaptor proteins and nanobodies, demonstrating their efficacy in human cells and potential for therapeutic applications.