Author

Siba Alharbi

King Abdullah University of Science and TechnologyORCID 0000-0002-5476-8045Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein design· 1

Frequent Co-Authors

Anandsukeerthi SandholuiD· 2 shared Stefan T. AroldiD· 2 shared Abdullah AldehaimaniD· 1 shared Adrien LugariiD· 1 shared Afaque A. MominiD· 1 shared Dennis Della CorteiD· 1 shared Haiyan WuiD· 1 shared Jacob A. SterniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Anandsukeerthi SandholuORCID

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2 papers

Recent·Most cited

Functional selection in SH3-mediated activation of the PI3 kinase

Safia Aljedani, Anandsukeerthi Sandholu, Abdullah Aldehaiman, Siba Alharbi, Victor C. Y. Mak, Haiyan Wu, Panpan Wang, Afaque A. Momin, Upendra Singh, Adrien Lugari, Łukasz Jaremko, Mariusz Jaremko, Xavier Morelli, Jonathan Backer, John Edward Ladbury, , Stefan T. Arold

This study identifies how SH3 domains activate PI3K by engaging in tertiary interactions with p85, revealing a mechanism for controlling activation through functional selection.

Communications Biology · Jan 19, 2026Peer-reviewedBiochemistry

Conformation-specific Design: a New Benchmark and Algorithm with Application to Engineer a Constitutively Active MAP Kinase

Jacob A. Stern, Siba Alharbi, Anandsukeerthi Sandholu, Stefan T. Arold, Dennis Della Corte

The paper introduces a benchmark and algorithm for designing proteins with conformational specificity, demonstrating success in redesigning MAP kinase ERK2 to maintain activity without phosphorylation.

bioRxiv · Apr 23, 2025 · PreprintSynthetic Biology