Michael Landowski

This study shows that DHA deficiency causes lipid remodeling and microglial activation in mice, leading to oxidative stress and visual dysfunction, with APOE-dependent lipid disposal and galectin-3 involvement.

This study shows TMEM135 deficiency leads to a lipogenic state with increased monounsaturated fatty acids and DHA depletion, which is buffered by peroxisomal metabolism and can be reversed by fish oil.

This study shows that mitochondrial fusion via MFN1 and MFN2 is essential for developing specialized mitochondrial structures and maintaining energy metabolism in rod photoreceptor cells.