TMEM135 deficiency remodels hepatic lipid homeostasis and protein malonylation through a DHA-sensitive lipogenic program buffered by peroxisomal metabolism
Ryo Hagimori, Michael Landowski, Siyu Song, Purnima Gogoi, Richard S. Brush, Sarah M. Bonvicino, Greg Barrett-Wilt, Sakae Ikeda, Ken-ichi Yamada, Chi–Liang Eric Yen, Tetsuya Takimoto, Martin‐Paul Agbaga, Akihiro Ikeda
This study shows TMEM135 deficiency leads to a lipogenic state with increased monounsaturated fatty acids and DHA depletion, which is buffered by peroxisomal metabolism and can be reversed by fish oil.
bioRxiv · Jul 23, 2026 · PreprintCell Biology