Author

Ryan M. Spengler

University of MichiganORCID 0000-0003-0181-5589Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Alton Etheridge· 2 shared David J. GalasiD· 2 shared Muneesh TewariiD· 2 shared Amanda Courtright· 1 shared Andrea J. BarczakiD· 1 shared Annika Jane Goicochea· 1 shared David H. BaxteriD· 1 shared DJ Erle· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Alton Etheridge

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2 papers

Recent·Most cited

Molecular BiologyThe EMBO JournalPeer-reviewedMay 3, 2019

Phospho-sRNA-seq reveals extracellular mRNA/lncRNA fragments as potential biomarkers in human plasma

Maria Dolores Giraldez, Ryan M. Spengler, Alton Etheridge…·Muneesh Tewari

The paper introduces phospho-sRNA-seq to detect fragmented mRNA and lncRNA in plasma, identifying tissue-specific exRNA signatures as potential biomarkers in bone marrow transplant patients.

103 citationstop 4%

humanbulk RNA-seq

𝕏 PostBluesky

GenomicsbioRxivPreprintMay 17, 2017

Accuracy, Reproducibility And Bias Of Next Generation Sequencing For Quantitative Small RNA Profiling: A Multiple Protocol Study Across Multiple Laboratories

MD Giraldez, Ryan M. Spengler, Alton Etheridge…·Muneesh Tewari

This study evaluates the accuracy, reproducibility, and bias of small RNA-seq across five protocols and nine labs, finding protocol-specific bias that can be mitigated with adapters and computational corrections.

5 citations

bulk RNA-seqstatistical model

𝕏 PostBluesky