Muneesh Tewari

Chromato-kinetic fingerprinting enables multiomic digital counting of single disease biomarker molecules

This paper introduces Bio-SCOPE, a platform that detects multiple biomarkers with high sensitivity and specificity, demonstrating its application in detecting miRNAs and proteins in disease contexts.

Ultrasensitive amplification-free quantification of a methyl CpG-rich cancer biomarker by single-molecule kinetic fingerprinting

This paper develops an amplification-free method to quantify DNA methylation at the BCAT1 promoter with high sensitivity and specificity, enabling improved early detection of methylated cancer DNA biomarkers.

Phospho-sRNA-seq reveals extracellular mRNA/lncRNA fragments as potential biomarkers in human plasma

The paper introduces phospho-sRNA-seq to detect fragmented mRNA and lncRNA in plasma, identifying tissue-specific exRNA signatures as potential biomarkers in bone marrow transplant patients.

A Pipeline for Fecal Host DNA Analysis by Absolute Quantification of LINE-1 and Mitochondrial Genomic Elements Using ddPCR

The paper develops a ddPCR-based pipeline for absolute quantification of host DNA in stool samples, validated across human and mouse specimens.

Accuracy, Reproducibility And Bias Of Next Generation Sequencing For Quantitative Small RNA Profiling: A Multiple Protocol Study Across Multiple Laboratories

This study evaluates the accuracy, reproducibility, and bias of small RNA-seq across five protocols and nine labs, finding protocol-specific bias that can be mitigated with adapters and computational corrections.