Author

Monica Varela

Leiden UniversityORCID 0000-0003-0215-9173Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Annemarie H. MeijeriD· 2 shared Arwin GroenewoudiD· 1 shared Mayra A. Aguirre-García· 1 shared Michiel van der VaartiD· 1 shared Sharon M. Portelli· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 6 mutual co-author links

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2 shared papersImmunology

Annemarie H. MeijerORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintApr 28, 2025

GBP1 drives lysosomal activity against cytosol-invading mycobacteria in macrophages

Mayra A. Aguirre-García, Sharon M. Portelli, Mónica Varela, Annemarie H. Meijer

This study shows GBP1 enhances lysosomal activity to clear mycobacteria in macrophages by promoting phagolysosome maturation and proteolytic function.

DOI 10.1101/2025.04.28.650982

humanexperimental assay

𝕏 PostBluesky

ImmunologybioRxivPreprintFeb 17, 2019

Extracellular mycobacterial DNA drives disease progression by triggering Caspase-11-dependent pyroptosis of infected macrophages

Monica Varela, Michiel van der Vaart, Arwin Groenewoud, Annemarie H. Meijer

The paper shows extracellular mycobacterial DNA triggers Caspase-11-dependent pyroptosis in macrophages, promoting TB progression through an Asc-independent pathway.

DOI 10.1101/514125

zebrafishmouse

𝕏 PostBluesky