Author

Léa Picard

Lyon 1 UniversitéORCID 0000-0003-0220-1589Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Alexandre LegrandiD· 1 shared Amandine Chantharath· 1 shared Andrea CimarelliiD· 1 shared Cameron L. M. GilchristiD· 1 shared Carine ReyiD· 1 shared Clara Loyer· 1 shared Emeline EsnoufiD· 1 shared François RoussetiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperEvolutionary Biology

Alexandre LegrandORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintApr 24, 2026

DTX3L-PARP9 co-evolve as a single adaptive unit linking ubiquitination and ADP-ribosylation in antiviral immunity

Léa Picard, Emeline Esnouf, Thibault Latrille, Stéphanie Jacquet

This study shows the DTX3L-PARP9 complex co-evolves as an adaptive unit in antiviral immunity, with adaptive residues enriched at interaction surfaces and catalytic regions.

DOI 10.64898/2026.04.23.720386

multiple speciescomparative / phylogenetic analysis

𝕏 PostBluesky

Evolutionary BiologyNature Ecology & EvolutionPeer-reviewedNov 11, 2025

Ancient convergence with prokaryote defense and recent adaptations to lentiviruses in primates characterize the ancestral immune factors SAMD9s

Alexandre Legrand, Rémi Demeure, Amandine Chantharath…·Lucie Etienne

This study identifies ancient immune convergence between prokaryotes and primates through SAMD9/9L proteins and reveals recent adaptations in bonobos and chimps enhancing HIV resistance.

4 citations

humanchicken / avian

𝕏 PostBluesky