NeuroscienceMolecular PainPeer-reviewed
Sensitization of Human and Rat Nociceptors by Low Dose Morphine is TLR4-dependent
Eugen V. Khomula, Dionéia Araldi, Paul G. Green, Jon D. Levine
The paper shows that low-dose morphine directly sensitizes human and rat nociceptors via TLR4, contributing to opioid-induced hyperalgesia.