Zhenbo Huang

The paper identifies two distinct engram ensembles within striatal medium spiny neurons that encode opposing memories for alcohol relapse and extinction.

This paper identifies a CRF-CIN pathway linking the extended amygdala to the dorsal striatum and shows alcohol disrupts CRF-induced cholinergic activity.

This paper identifies hyperactivity in the mPFC-to-DMS circuit in 5xFAD mice as a cause of cognitive inflexibility, showing that inhibiting this circuit improves cognitive function and reduces Aβ accumulation.

This study examines how chronic alcohol exposure affects corticostriatal circuits and pathology in two Alzheimer's disease mouse models, revealing distinct effects on Aβ and tau-driven pathologies.

The paper inhibits striatal engrams involved in alcohol-taking behaviors to show reduced future alcohol-seeking and enhanced extinction.

This study shows that burst firing of striatal cholinergic interneurons promotes extinction learning, while their pause is critical for reversing goal-directed behavior, and alcohol disrupts this process.

This paper shows that drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic interneurons through enhanced inhibitory transmission from direct-pathway medium spiny neurons.

This study shows that chronic opioid use induces GABAergic plasticity in striatal neurons, leading to hypodopaminergic states and negative affect, which contribute to relapse.

This study shows chronic alcohol consumption impairs cognitive flexibility by reducing thalamic excitation of cholinergic neurons in the dorsomedial striatum.