Diffusion tensor imaging of whole human brains during long-term formaldehyde fixation: Temporal evolution of diffusion parameters, post-mortem conditions, and dependence on tissue structure
Nina Lüthi, Francisco J. Fritz, Björn Fricke, Jan Malte Oeschger, Tobias Streubel, Herbert Mushumba, Klaus Püschel, Siawoosh Mohammadi
This study examines how post-mortem tissue conditions and fixation progression affect diffusion tensor imaging parameters in whole human brains, finding that mean diffusivity is a robust marker while fractional anisotropy requires microstructure-aware interpretation.
bioRxiv · Sep 4, 2026 · PreprintNeuroscience