Carsten Jäger

Observations of anisotropic paramagnetic and diamagnetic susceptibility in the primate brain

This study uses MRI and computational methods to show that paramagnetic substances contribute to susceptibility anisotropy in primate brain tissue, alongside diamagnetic components.

Single-cell quantification of the iron-neuromelanin balance in dopaminergic neurons across the lifespan

The paper quantifies iron and neuromelanin in dopaminergic neurons across chimpanzee lifespan, finding stable iron-to-neuromelanin ratios and no evidence of saturation or increased toxicity with age.

Giving you five: A neuroimaging atlas of the nigrosomes in the substantia nigra based on 3D histology

This paper creates a 3D histological atlas of nigrosomes in the substantia nigra aligned to MNI152 space, enabling MRI analysis of these structures in Parkinson's disease.

Spatial and single-nucleus transcriptomic profile of a chimpanzee frontal pole

This study presents the first spatial transcriptomic data from a chimpanzee brain, mapping gene expression and cell types in the frontal pole and integrating with single-nucleus transcriptomics to explore evolutionary differences.

Human short association fibers are thinner and less myelinated than long fibers

The paper analyzes human white matter fibers to compare thickness and myelination between long and short fibers, finding shorter fibers are thinner and less myelinated but have similar g-ratio.

Neuroinfectiology of an atypical anthrax-causing pathogen in wild chimpanzees

This study investigates the neuroinfectiology of Bcbva in wild chimpanzees, finding it causes meningitis and breaches the blood-brain barrier more effectively than B. anthracis.

High Angular Resolution Susceptibility Imaging and Estimation of Fiber Orientation Distribution Functions in Primate Brain

This paper introduces HARSI, a new method for estimating fiber orientation distribution functions in fixed primate brains, showing it can capture complex fiber configurations comparable to HARDI.

B1+-correction of MT saturation maps optimized for 7T postmortem MRI of the brain

The paper develops and validates a calibration-based correction model for MTsat maps in postmortem 7T MRI data of chimpanzee brains to address B1+ inhomogeneities.

A representative reference for MRI-based human axon radius assessment using light microscopy

The paper introduces a CNN-based method to estimate MRI-visible effective axon radius using light microscopy data, showing higher accuracy than traditional arithmetic mean radius estimates.

Toward an early diagnostic marker of Parkinson's: measuring iron in dopaminergic neurons with MR relaxometry

The paper links MRI relaxation rate in substantia nigra to iron concentration in dopaminergic neurons, enabling early Parkinson's disease detection.

Increased Sensitivity and Signal-to-Noise Ratio in Diffusion-Weighted MRI using Multi-Echo Acquisitions

This paper introduces a Multi-Echo dMRI method to improve SNR and reduce noise bias in post-mortem diffusion MRI, validated on a chimpanzee brain.

Combining Deep Learning and Active Contours Opens The Way to Robust, Automated Analysis of Brain Cytoarchitectonics

This paper develops a method combining deep learning and active contours for automated segmentation of neural cell bodies from light-sheet microscopy data.