Thomas Sauvigny

This study compares the effects of AMPA receptor inhibitors on seizure-like events in murine and human brain slices, finding species-specific differences in drug efficacy.

The paper investigates electrical signaling between mid-capillary pericytes and endothelial cells in the neurovascular unit, showing syncytial coupling and its role in transmitting seizure-associated signals without relying on VGCCs.

This study examines the effects of LGI1 autoantibodies on human CA3 neurons using ex vivo slices, revealing increased neuronal activity and distinct mechanisms from potassium channel blockers.

The paper investigates the effects of tau oligomers on sharp-wave ripples in mouse and human hippocampal slices, finding reversible impairments in SWR parameters depending on species and tau preparation.

The paper compares Kv and Kir2.1 channel activity in human and mouse microglia, finding significant differences in their regulation and functional responses.

This study shows NASPM inhibits NMDA receptors rather than CP-AMPARs in human brain tissue, challenging its use as a specific CP-AMPAR inhibitor and questioning its therapeutic potential.

This study identifies ADAM10-mediated shedding of human PrP at Y226 and shows sPrP associates with misfolded protein aggregates in neurodegenerative diseases.

ACID is an open-source MATLAB toolbox for processing and modeling diffusion MRI data from brain, spinal cord, and ex vivo specimens, incorporating artifact correction, biophysical models, and BIDS compatibility.

The paper identifies an epigenetic neural signature in glioblastoma that correlates with poor prognosis and therapeutic vulnerability.