Corinne Simonti

The paper examines allelic variation in tRNA genes across three nematode species, finding high mutation rates and purifying selection, with functional mismatches between tRNA anticodons and amino acids.

The paper analyzes tRNA allelic variation in C. elegans to model how transcription-associated mutagenesis (TAM) influences tRNA microevolution and structural stability.

The paper develops a genotyping array tailored for African populations to identify cancer risk variants, finding population-specific allele frequency differences and lower prostate cancer risk in Senegal compared to Nigeria.

The paper predicts placental enhancers using machine learning, identifying 33,010 genomic regions, including 4,562 high-confidence enhancers, enriched near genes and SNPs linked to placental development and birth disorders.

The paper investigates selection mechanisms underlying human brain structure and behavioral traits, finding evidence for ancient and recent polygenic adaptation but not classical selective sweeps.