Ekaterina A. Khramtsova

This study identifies 1,242 novel genetic variants and 31 novel genes associated with frailty through genome-wide association and proteomics integration.

This study conducts a genome-wide meta-analysis across three biobanks to identify new genetic loci associated with lumbar disc herniation, expanding the known genetic landscape.

This study identifies 262 STRs significantly associated with MRI-derived grey matter volumes in UK Biobank participants, with 12 associations replicated and no nearby SNPs in linkage disequilibrium.

This study examines APOE Christchurch carriers in UK Biobank to assess their risk of Alzheimer's disease, cardiovascular disease, and dyslipidemia, finding lower apoB levels and reduced AD risk.

This study identifies a genome-wide significant variant for OC traits and shows shared genetic risk between OC traits and OCD.

The paper examines sex-differentiated genetic effects across neuropsychiatric and behavioral traits using GWAS summary statistics and finds small, polygenic sex differences with enriched neuron-related genes.

This study identifies genetic variants influencing human cortical surface area by integrating evolutionary annotations with neuroimaging genetic data, revealing recent polygenic selection on brain regions involved in language and vision.

This study investigates sex differences in the genetic architecture of OCD using large-scale genomic data and finds evidence for sex-specific regulatory variant enrichment without genome-wide associations.

The paper investigates selection mechanisms underlying human brain structure and behavioral traits, finding evidence for ancient and recent polygenic adaptation but not classical selective sweeps.