Author

Martin A. Rooimans

Amsterdam University Medical CentersORCID 0000-0003-0267-5661Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Job de LangeiD· 2 shared Klaas de LintiD· 2 shared Rob M.F. WolthuisiD· 2 shared Thom M. MolenaariD· 2 shared Adi V Tarrab· 1 shared Anisha R. Ramadhin· 1 shared Daan L TangiD· 1 shared Davy Rockx· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersMolecular Biology

Job de LangeORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 7, 2026

Residual cohesin function and PARP1 levels determine PARP inhibitor sensitivity in STAG2-deficient cancers

Thom M. Molenaar, Zoi Karagiorgou, S. Jacobs…·Job de Lange

This study identifies residual cohesin function and PARP1 levels as key factors determining PARP inhibitor sensitivity in STAG2-deficient cancers, highlighting the need for biomarker-based patient stratification.

DOI 10.64898/2026.09.04.749084

humanexperimental assay

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Cell BiologybioRxivPreprintMay 21, 2026

The SKA complex is a mitotic vulnerability of chromosomally unstable cancers

Maud Schoot Uiterkamp, Elsa S. Coolen, Klaas de Lint…·Gerben Vader

The paper identifies the SKA complex as a mitotic vulnerability in chromosomally unstable cancers, showing its selective impact on these cells through prolonged mitosis.

DOI 10.64898/2026.05.21.726809

humanexperimental assay

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Molecular BiologyNucleic Acids ResearchPeer-reviewedSep 13, 2023

CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin

Janne J. M. van Schie, Klaas de Lint, Thom M. Molenaar…·Job de Lange

The paper identifies PAXIP1-PAGR1 as a novel cohesin regulator through CRISPR screens in cohesion defective cells, showing its role in chromatin association of cohesin independent of DNA replication.

15 citations

humanCRISPR screen

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