Janne J. M. van Schie

This study shows that PAF1C restores RNAPII elongation after DNA damage without requiring transcription-associated histone mark deposition.

This study identifies STK19 as a factor facilitating the transition from initial TCR complex assembly to downstream repair steps by enabling RNAPII clearance.

The paper identifies PAXIP1-PAGR1 as a novel cohesin regulator through CRISPR screens in cohesion defective cells, showing its role in chromatin association of cohesin independent of DNA replication.

ShrinkCRISPR analyzes CRISPR-Cas9 screen data to detect differential gene fitness effects while accounting for variation across cell populations and replicates.

This study identifies ELOF1 as a factor that directs CRL4CSA to ubiquitylate RNAPII at K1268, facilitating TCR and protecting CSB-deficient cells from transcription-replication collisions.