Author
Amsterdam University Medical CentersORCID 0000-0002-9002-8829Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Thom M. Molenaar, Zoi Karagiorgou, S. Jacobs, Daan L Tang, Isha Sadal, Martin A. Rooimans, Job de Lange
This study identifies residual cohesin function and PARP1 levels as key factors determining PARP inhibitor sensitivity in STAG2-deficient cancers, highlighting the need for biomarker-based patient stratification.
bioRxiv · Sep 7, 2026 · PreprintMolecular Biology
Janne J. M. van Schie, Klaas de Lint, Thom M. Molenaar, Macarena Moronta Gines, Jesper A. Balk, Martin A. Rooimans, Khashayar Roohollahi, Govind M. Pai, Lauri Borghuis, Anisha R. Ramadhin, Francesco Corazza, Josephine C. Dorsman, Kerstin S. Wendt, Rob M.F. Wolthuis, Job de Lange
The paper identifies PAXIP1-PAGR1 as a novel cohesin regulator through CRISPR screens in cohesion defective cells, showing its role in chromatin association of cohesin independent of DNA replication.
Nucleic Acids Research · Sep 13, 2023Peer-reviewedMolecular Biology
Renaud Tissier, Janne J. M. van Schie, Rob M.F. Wolthuis, Job de Lange, Renée de Menezes
ShrinkCRISPR analyzes CRISPR-Cas9 screen data to detect differential gene fitness effects while accounting for variation across cell populations and replicates.
BMC Bioinformatics · Feb 3, 2023Peer-reviewedBioinformatics
Yana van der Weegen, Klaas de Lint, Diana van den Heuvel, Yuka Nakazawa, Tycho E.T. Mevissen, Janne J. M. van Schie, Marta San Martín Alonso, Daphne E.C. Boer, Román González‐Prieto, Ishwarya Venkata Narayanan, Noud H.M. Klaassen, Annelotte P. Wondergem, Khashayar Roohollahi, Josephine C. Dorsman, Yuichiro Hara, , Martijn S. Luijsterburg
This study identifies ELOF1 as a factor that directs CRL4CSA to ubiquitylate RNAPII at K1268, facilitating TCR and protecting CSB-deficient cells from transcription-replication collisions.
Nature Cell Biology · Jun 1, 2021Peer-reviewedMolecular Biology