Zhenghong Yuan

This study shows that combining RNAi-mediated HBV antigen shutdown with PEGIFNalpha enhances antiviral immunity by improving T and B cell interactions and function in a mouse model of chronic hepatitis B.

This study determines the structure of the HBx-CRL4-Smc5/6 complex and identifies a druggable interface for antiviral therapy against HBV.

This study identifies DAZAP2 as a pan-coronavirus restriction factor that inhibits viral entry and genomic replication, with physiological relevance confirmed in mouse models and human cells.

This study simulates scRNA-seq data to evaluate how sequencing parameters and clustering algorithms affect cell clustering accuracy.