Explicitly modeling genetic ancestry to improve polygenic prediction accuracy for height in a large, admixed cohort of US Latinos: Findings from HCHS/SOL
Xin Wang, Tamar Sofer, Oleksandr Frei, Robert C. Kaplan, Krista M. Perreira, Nora Franceschini, Humberto Parada, Laura Y. Zhou, Ole A. Andreassen, Hector Gonzalez, Anders Martin Dale, Iris Broce
This paper improves polygenic prediction of height in an admixed Latino cohort by incorporating genetic ancestry, achieving a 0.1 increase in R² compared to using polygenic scores alone.
Human Genetics and Genomics Advances · Mar 27, 2026Peer-reviewedGenetic & Genomic Medicine