Iris Broce

This paper evaluates combining expression-based surrogate variables and genotype-based principal components in differential expression analysis, finding the combined approach improves replicability and biological recall in ALS datasets.

This paper improves polygenic prediction of height in an admixed Latino cohort by incorporating genetic ancestry, achieving a 0.1 increase in R² compared to using polygenic scores alone.

This study identifies distinct genetic overlaps between Alzheimer's and Parkinson's disease and metabolic markers, revealing disease-specific pathways involving lipid metabolism and synaptic processes.

This study compares old and new local ancestry inference methods in Hispanic/Latino populations using HCHS/SOL data, finding high similarity but some regional discrepancies.

The paper identifies a C9orf72 gene network correlated with cortical thickness in C9-FTD and implicates vulnerable cell types.

The paper compares TDP-43's transcriptional and splicing effects in muscle and neuronal cells, showing tissue-specific roles in disease.

The paper evaluates polygenic risk scores for Alzheimer's Disease and Mild Cognitive Impairment in Hispanics/Latinos, finding that PRS based on AD GWAS predict MCI, with APOE region SNPs driving the association.

This study identifies genetic variants and networks associated with ALS using GWAS data, revealing novel loci and functional sub-networks linked to disease.

The study examines the frontal aslant tract (FAT) laterality in children and links it to executive function and attention problems through mediation by executive dysfunction.

The paper identifies genetic variants associated with Alzheimer's disease and cardiovascular risk factors, showing lipid-related enrichment and pleiotropy beyond APOE.

The paper identifies a genetic variant near CXCR4 associated with increased risk for PSP and PD, showing dysregulation of CXCR4 and microglia-related genes in neurodegenerative diseases.

This study identifies genetic overlaps between frontotemporal dementia and immune-mediated diseases, finding strong enrichment with rheumatoid arthritis and moderate enrichment with other immune conditions.

This study evaluates whether a polygenic hazard score (PHS) can enhance the prediction of amyloid and tau deposition and progression to Alzheimer’s dementia when combined with biomarkers in nondemented individuals.