Laura Pasetto

This study investigates the effects of HDAC inhibition and its combination with arimoclomol on TDP-43 proteinopathy in vitro and in vivo, finding delayed pathology and synergistic neuroprotection.

This study shows that targeting NMJ regeneration and CXCR4 can improve motor function and survival in ALS models.

The paper performs a multiomic analysis of ALS patients and mouse models to identify sex differences, molecular subclusters, and the MAPK pathway as a therapeutic target.

This study shows that defective cyclophilin A (PPIA) leads to TDP-43 proteinopathy, contributing to ALS and FTD by disrupting TDP-43 function and causing neurodegeneration.