Evolutionary BiologyGut MicrobesPeer-reviewed
Evolution of E. coli in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevance
Rahul Unni, Nadia Andrea Andreani, Marie Vallier…·John F. Baines
This study shows that E. coli evolves specific genetic and phenotypic traits in an inflamed gut, leading to antibiotic collateral sensitivity and potential therapeutic implications.
11 citations