Author

Alaa Badreddine

Centre National de la Recherche ScientifiqueORCID 0000-0003-0336-4582Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Organism:mouse· 1

Frequent Co-Authors

Amélie BonnefondiD· 2 shared François N. PattouiD· 2 shared Julie A. Kerr-ConteiD· 2 shared Mehdi DerhourhiiD· 2 shared Philippe FrogueliD· 2 shared Souhila Amanzougarene· 2 shared Akinchan Kumar· 1 shared Amna KhamisiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenomics

Amélie BonnefondORCID

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3 papers

Recent·Most cited

GenomicsiSciencePeer-reviewedJun 30, 2023

The HDAC inhibitor trichostatin A impairs pancreatic β-cell function through an epigenome-wide reprogramming

Frédérik Oger, Maeva Moreno, Mehdi Derhourhi…·Jean‐Sébastien Annicotte

This study shows that HDAC inhibition by trichostatin A disrupts β-cell function and identity through epigenome-wide remodeling in both mouse and human β-cell models.

14 citations

mousehuman

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Genetic & Genomic MedicinemedRxivPreprintDec 30, 2022

Epigenetics of PNLIPRP1 in human pancreas reveals a molecular path between type 2 diabetes and pancreatic cancer

Lucas Maurin, Lorella Marselli, Lijiao Ning…·Amna Khamis

The paper identifies hypermethylation of PNLIPRP1 in T2D patients and shows its association with acinar-to-ductal metaplasia and PDAC risk.

1 citation

humanDNA methylation

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GenomicsbioRxivPreprintJul 11, 2019

Patient-matched analysis identifies deregulated networks in prostate cancer to guide personalized therapeutic intervention

Akinchan Kumar, Alaa Badreddine, Karim Azzag…·Hinrich Gronemeyer

The paper identifies patient-specific deregulated regulatory networks in prostate cancer to inform personalized therapeutic strategies.

7 citations

humanbulk RNA-seq

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