ALDH1 subtype-specific inhibitor targets key cancerous epithelial cell populations in aggressive subtypes of breast cancer
Raquel Pequerul, A. Constantinescu, Bassam Janji, Akinchan Kumar, Xavier Parés, Òscar Palacios, Delphine Colignon, Axelle Berrou, Guy Fournet, Paul BERCHARD, Guillaume Martin, Ismail Ceylan, Rocio Rebollido-Ríos, Jaume Farrés, Mileidys Perez-Alea
This study identifies ALDH1A3 as a therapeutic target in aggressive breast cancers and develops ABD0171, a selective inhibitor showing antitumor and antimetastatic effects.
bioRxiv · Oct 18, 2024 · PreprintCancer Biology