GABAergic signaling promotes early-life seizures in epileptic SYNGAP1+/- mice
Brennan J. Sullivan, Pavel A. Kipnis, Simon G. Ammanuel, Shilpa D. Kadam
This study investigates early-life seizures in SYNGAP1 heterozygous mice and finds that GABAergic signaling promotes seizure generation, with subclinical seizures refractory to some treatments but responsive to others.
bioRxiv · Nov 14, 2020 · PreprintNeuroscience