Pavel A. Kipnis

This study shows that enhancing KCC2 function with CLP290 rescues PB-resistant neonatal seizures and reduces epileptogenesis in a mouse model.

This study investigates early-life seizures in SYNGAP1 heterozygous mice and finds that GABAergic signaling promotes seizure generation, with subclinical seizures refractory to some treatments but responsive to others.

The paper identifies GluA2 upregulation in parvalbumin interneurons as a cause of gamma dysregulation in Syngap1+/- mice and shows that Perampanel rescues this dysfunction.

This study shows that TrkB agonists reduce PB-refractory seizures in neonatal mice by modulating KCC2 stability and TrkB pathway activation post-ischemia.