Shilpa D. Kadam

This study shows that enhancing KCC2 function with CLP290 rescues PB-resistant neonatal seizures and reduces epileptogenesis in a mouse model.

This study investigates early-life seizures in SYNGAP1 heterozygous mice and finds that GABAergic signaling promotes seizure generation, with subclinical seizures refractory to some treatments but responsive to others.

The paper validates the focal specificity of transcranial functional photoacoustic voltage-sensitive dye imaging in rat hippocampus by correlating NMDA-evoked neural activity with glutamate release and EEG signals.

The paper identifies GluA2 upregulation in parvalbumin interneurons as a cause of gamma dysregulation in Syngap1+/- mice and shows that Perampanel rescues this dysfunction.

This study shows that TrkB agonists reduce PB-refractory seizures in neonatal mice by modulating KCC2 stability and TrkB pathway activation post-ischemia.

This paper demonstrates the use of functional photoacoustic imaging with a near-infrared voltage-sensitive dye to record in vivo neural activity in rats without craniotomy, showing distinguishable responses in seizure models.