Tumor Cell Clustering Enhances Metastatic Competence by Regulating the H3K36 Histone Demethylase KDM2A
Carolyn J. Kravitz, Kiran D. Patel, Emily Wingrove, Dejian Zhao, Tang Tang, Sampada Chande, Minghui Zhao, Yuchen Huo, Thomas F. Westbrook, Qin Yan, Don X. Nguyen
The paper identifies KDM2A as a key regulator of metastatic competence in tumor cell clusters through epigenetic modulation of oxidative phosphorylation and cell junction integrity.
bioRxiv · Jan 23, 2026 · PreprintCancer Biology