Degenerated intervertebral disc environment impairs notochordal cell-derived extracellular vesicles release and their matrix anabolic effect
Daniele Corraini, Chantal Voskamp, Anouk Eversdijk…·Marianna A. Tryfonidou
This study shows that degenerative disc conditions reduce notochordal cell-derived extracellular vesicles release and their ability to promote matrix production in nucleus pulposus cells.