Developmental BiologyeLifePeer-reviewed
Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA
Ki-Sun Park, Beenish Rahat, Hyung Chul Lee…·Karl E. Pfeifer
The paper shows that maternal loss of imprinting at the H19/IGF2 locus causes cardiac pathologies in mice, with Igf2 driving transient hypertrophy and H19 causing progressive fibrosis and reduced ventricular function.
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