Silvia K. Nicolis

The paper uses CRISPR-LICHT to screen SOX2 targets in human brain organoids, identifying 28 new genes involved in neural progenitor lineage expansion and survival.

The paper identifies SOX2 and NR2F1 as regulators of gene expression in the early postnatal visual thalamus, showing their shared target genes and regulatory mechanisms.

The paper maps enhancer-promoter interactions from mouse neural stem cells to the human genome, identifying disease-associated variants that affect enhancer function in neurodevelopmental disorders.

This study identifies Fos as a key regulator of neural stem cell self-renewal, showing it rescues proliferation and interacts with Sox2 through a gene regulatory network involving Socs3.

This study identifies an early Sox2-dependent gene expression program critical for hippocampal dentate gyrus development using mouse models and functional analysis.