Author

Hari Prasad

Johns Hopkins UniversityORCID 0000-0003-0486-1919Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Hari Prasad1 paper · Indian Institute of Science Bangalore

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Rajini RaoiD· 2 shared

Activity by Year

2018-2018 · peak 2/yr

2 papers

Recent·Most cited

NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedJun 26, 2018

The Amyloid Clearance Defect in ApoE4 Astrocytes is Corrected by Epigenetic Restoration of NHE6

Hari Prasad, Rajini Rao

This study identifies NHE6 as a key effector of ApoE4 in Alzheimer's disease, showing that restoring NHE6 expression improves endosomal pH, LRP1 trafficking, and amyloid clearance in ApoE4 astrocytes.

202 citationstop 1%

mouseproteomics

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Molecular BiologyJournal of Biological ChemistryPeer-reviewedMar 22, 2018

A conserved mechanism for regulation of endo-lysosomal pH by histone deacetylases

Hari Prasad, Rajini Rao

The paper identifies a conserved mechanism where histone deacetylases regulate endosomal pH through NHE expression, offering therapeutic strategies for neurodegenerative diseases and fungal infections.

34 citations

yeastDrosophila

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