Author

Daniel Guion

University of California, Los AngelesORCID 0000-0003-0647-6256Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Alfredo Arrigo SaduniD· 1 shared Anastassia N. AlexandrovaiD· 1 shared Anissa Martinez· 1 shared Babak AlipanahiiD· 1 shared Benjamin W. JesteriD· 1 shared Cameron Cordray· 1 shared Charles Lin· 1 shared Christof AngermuelleriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

Alfredo Arrigo SadunORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintApr 23, 2026

Molecular Basis of Mitochondrial Complex I Disruption by m.14484T>C-Induced Leber Hereditary Optic Neuropathy

Pujan Ajmera, Daniel Guion, Steven Barnes…·Anastassia N. Alexandrova

This study identifies how the m.14484T>C mutation in ND6 subunit of complex I disrupts quinone binding and proton pumping, leading to LHON through altered hydrogen bond networks and redox chemistry.

1 citation

humanbiophysical modeling

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BioinformaticsbioRxivPreprintDec 1, 2023

High-throughput ML-guided design of diverse single-domain antibodies against SARS-CoV-2

Christof Angermueller, Zelda Mariet, Benjamin W. Jester…·Lucy J. Colwell

This study uses ML to design diverse VHH antibodies that neutralize SARS-CoV-1 and SARS-CoV-2 variants, including Delta and Omicron BA.1.

6 citations

machine learning (classical)drug response / drug discovery

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