Author

Alfredo Arrigo Sadun

University of California, Los AngelesORCID 0009-0005-5475-761XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1

Frequent Co-Authors

Anastassia N. AlexandrovaiD· 1 shared Caterina TononiD· 1 shared Chiara La MorgiaiD· 1 shared Claudia M. TestaiD· 1 shared Claudio BianchiniiD· 1 shared Daniel GuioniD· 1 shared David Neil MannersiD· 1 shared Gilles VandewalleiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

Anastassia N. AlexandrovaORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintApr 23, 2026

Molecular Basis of Mitochondrial Complex I Disruption by m.14484T>C-Induced Leber Hereditary Optic Neuropathy

Pujan Ajmera, Daniel Guion, Steven Barnes…·Anastassia N. Alexandrova

This study identifies how the m.14484T>C mutation in ND6 subunit of complex I disrupts quinone binding and proton pumping, leading to LHON through altered hydrogen bond networks and redox chemistry.

1 citation

humanbiophysical modeling

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NeurosciencebioRxivPreprintSep 4, 2020

Melanopsin retinal ganglion cell-driven contribution to visual and cognitive brain responses in LHON

Stefania Evangelisti, Chiara La Morgia, Claudia M. Testa…·Raffaele Lodi

The paper investigates the role of melanopsin retinal ganglion cells (mRGCs) in visual and cognitive brain responses in LHON patients using fMRI under different light conditions.

DOI 10.1101/2020.09.04.282830

humanimaging

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