Eyleen J. O’Rourke

This study shows that activating ADH-1 extends healthspan in multiple species by improving proteostasis and reducing age-related diseases.

This study creates a single-cell gene expression atlas of C. elegans, identifying cell types, housekeeping genes, and intercellular interactions using scRNA-seq and ChIP-seq data.

The paper introduces a computational framework to infer the spatial code of cell-cell interactions using transcriptomic data from C. elegans, validated with experimental confirmation.

StanDep improves context-specific metabolic models by using transcriptomic variability to identify core reactions, increasing inclusion of housekeeping and lowly expressed reactions.