Chau Huynh

Multi-scale dissection, compaction and derivatization of mammalian developmental enhancers

The paper systematically perturbs enhancer sequences to study their functional properties and robustness, revealing insights into regulatory sequence space and enhancer activity.

Extensive length and homology dependent chimerism in pool-packaged AAV libraries

The paper shows that AAV libraries packaged as pools exhibit extensive chimerism due to length and homology dependence, affecting most genomes.

Binding profiles for 954 Drosophila and C. elegans transcription factors revealtissue specific regulatory relationships

The paper presents a catalog of transcription factor binding sites in Drosophila and C. elegans, revealing tissue-specific regulatory relationships using machine learning.

Whole-body gene expression atlas of an adult metazoan

This study creates a single-cell gene expression atlas of C. elegans, identifying cell types, housekeeping genes, and intercellular interactions using scRNA-seq and ChIP-seq data.

A lineage-resolved molecular atlas of C. elegans embryogenesis at single cell resolution

The paper maps lineage and transcriptome relationships in C. elegans embryogenesis using single-cell transcriptomics, revealing lineage-transcriptome correlation breakdown in late divisions.

Comprehensive single cell transcriptional profiling of a multicellular organism by combinatorial indexing

This paper introduces sci-RNA-seq, a combinatorial indexing method for single-cell RNA sequencing, and applies it to profile 42,035 C. elegans cells, identifying 27 cell types and their specific genes.