Hyun Jun Jung

The paper develops a transcriptome-based method to match bulk RNA-seq data from kidney cell lines to single-cell reference datasets, identifying accurate cell type identities and evaluating method performance.

The paper uses snRNA-seq to analyze DCT cells, revealing distinct functional subtypes DCT1 and DCT2 with different gene expression patterns and developmental origins.

The paper identifies circadian gene expression patterns in mouse renal proximal tubules and provides a web resource for these data.

The paper identifies PPAR activation as a key driver of compensatory renal proximal tubule hypertrophy using multi-omic analyses in a mouse model.

The paper uses RNA-Seq and protein mass spectrometry on microdissected kidney tubules to identify signaling pathways involved in lithium-induced diabetes insipidus, showing NF-κB activation and reduced aquaporin-2 expression.

The paper identifies cell-type selective markers in whole-kidney RNA-Seq data and shows that proximal tubule cells dominate mRNA expression, affecting interpretation of bulk and single-cell RNA-Seq.