This study examines how simulated Mars conditions affect immune responses to bacterial pathogens, finding altered cytokine secretion, ROS production, and phagocytic activity in human immune cells.

bioRxiv · Feb 5, 2025 · PreprintImmunology

Circadian Gene Expression in Mouse Renal Proximal Tubule

Molly A. Bingham, Kim Neijman, Chin‐Rang Yang, Angel M. Aponte, Angela Mak, Hiroaki Kikuchi, Hyun Jun Jung, Brian G. Poll, Viswanathan Raghuram, Euijung Park, Chung‐Lin Chou, Lihe Chen, Jens Leipziger, Mark A. Knepper, Margo Dona

The paper identifies circadian gene expression patterns in mouse renal proximal tubules and provides a web resource for these data.

American Journal of Physiology-Renal Physiology · Feb 2, 2023Peer-reviewedSystems Biology

Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations

Kalyan Dulla, Ralph W. N. Slijkerman, Hester C. van Diepen, Sílvia Albert, Margo Dona, Wouter Beumer, Janne J. Turunen, Hee Lam Chan, Iris A. E. Schulkens, Lars Vorthoren, Cathaline den Besten, Levi C.M. Buil, Iris Schmidt, Jiayi Miao, Hanka Venselaar, , Erwin van Wijk

This study demonstrates that QR-421a induces exon 13 skipping in USH2A transcripts, restoring retinal function in zebrafish and non-human primates.

Molecular Therapy · Apr 23, 2021Peer-reviewedGenetics