Author

Parth Rakesh Desai

National Institutes of HealthORCID 0000-0003-0528-5538Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1 Organism:virus· 1

Frequent Co-Authors

John F. MarkoiD· 1 shared Jonathan E. SilveriD· 1 shared Keir Cajal NeumaniD· 1 shared Mihir PrajapatiiD· 1 shared Siddhartha DasiD· 1 shared Yeonee Seol· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 10 mutual co-author links

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1 shared paperBiophysics

John F. MarkoORCID

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2 papers

Recent·Most cited

BiophysicsbioRxivPreprintSep 8, 2026

Type II topoisomerase substrate geometry revealed through combined experiment and computation.

Mihir Prajapati, Yeonee Seol, Jonathan E. Silver…·Keir Cajal Neuman

This study determines the 3D geometry of DNA crossings preferred for strand passage by topo II enzymes using single-molecule experiments and simulations.

DOI 10.64898/2026.09.04.749274

E. colivirus

𝕏 PostBluesky

BiophysicsBiophysical JournalPeer-reviewedApr 30, 2025

Molecular Crowding Suppresses Mechanical Stress-Driven DNA Strand Separation

Parth Rakesh Desai, John F. Marko

This study investigates how molecular crowding and dehydrating co-solutes affect DNA supercoiling and base-pair stability using single molecule magnetic tweezers.

3 citations

experimental assaychromatin & epigenetic regulation

𝕏 PostBluesky