Peng Wang

The paper constructs a lifespan single-cell atlas of immune cells, identifies an early-childhood immunometabolic transition around age 6, and develops an age-referenced framework for immune-state analysis.

This paper develops a method to generate human brain organoids with vasculature and microglia using genetic code expansion, showing enhanced neurovascular interactions and ZIKV-induced dysfunction.

This study uses a blood-brain barrier microphysiological system to show radiation induces sterile inflammation via mitochondrial DNA release and cGAS-STING signaling, with potential therapeutic targets identified.