Helge Hass

The paper investigates how Pou5f3 and Nanog regulate enhancer types during zygotic genome activation through an activator-blocker mechanism.

The paper shows Pou5f3 and Sox19b independently regulate enhancer chromatin accessibility, affecting zygotic gene expression in zebrafish embryos.

The paper presents 20 ODE-based benchmark models for evaluating dynamic modeling methods in systems biology, including parameter estimation and uncertainty analysis.

The paper predicts ligand-dependent tumor growth in cell lines and patient samples using a mechanistic signaling model and Bagged Decision Trees, finding a correlation between growth factor expression and predicted response.