Carolin Loos

The paper models H4K20 methylation kinetics during Xenopus embryogenesis, showing demethylation is essential in non-cycling cells but dispensable in rapidly dividing cells.

The paper models the propagation and stability of K27 and K36 methylation landscapes using computational methods and mass spectrometry data.

This paper generalizes a hierarchical population model to allow for alternative distribution assumptions, improving robustness and calibration performance in simulations and real data.

The paper compares five null models for combination drug therapy, finding the Hand model to be biochemically most plausible due to its generalization of dose equivalence and resolution of model ambiguities.

The paper presents 20 ODE-based benchmark models for evaluating dynamic modeling methods in systems biology, including parameter estimation and uncertainty analysis.

This paper introduces a hierarchical optimization method for parameter estimation in ODE models using relative data, showing improved convergence and computational efficiency.

This study introduces a hierarchical population model to identify latent causes of cell-to-cell variability in heterogeneous populations using single-cell data.