Jonathan Matthew Hernandez

This study evaluates TR-107, a mitochondrial ClpP agonist, showing antitumor effects in ACC cell lines and organoids, with synergistic activity when combined with IGF-1R inhibitors.

The paper uses phosphoproteomic data and KMEA to identify tumor-specific kinase activity in GEP-NETs, revealing potential therapeutic targets.

This study shows that the anti-MHC-I antibody M1/42 enhances anti-tumor immunity by activating NK and adaptive immune cells, reducing metastasis in mouse models of cancer.

Imaging of mitochondria and lipid droplets (LDs) across mouse liver lobules shows fasting, not Western diet, expands mitochondria-LD contacts; PLIN5 phosphomutants tune contacts and lipid storage.

This study uses single-cell spatial proteomics to map human liver zonation patterns and shows their disruption in fibrosis.

The paper develops a perfusion circuit system to preserve tumor microenvironments in 3D patient-derived tumor models for up to 48 hours, enabling complex drug interrogations.

The paper identifies PSMB8 as a potential therapeutic target in gastric cancer and shows carfilzomib's efficacy in reducing tumor growth and inducing apoptosis in a mouse model.