BiophysicsPLoS Computational BiologyPeer-reviewed
Allosteric modulation of proton binding confers Cl- activation and glutamate selectivity to vesicular glutamate transporters
Bart Borghans, Daniel Kortzak, Piersilvio Longo…·Christoph M. Fahlke
This study investigates how Cl- binding modulates VGLUT1's protonation states, enhancing its glutamate transport and Cl- channel functions through allosteric effects.