Christoph M. Fahlke

This study identifies SLC26A11 as a dual-function protein that acts as both a sulfate transporter and a chloride channel, with implications for treating brain edema and lysosomal storage diseases.

The paper functionally characterizes the Drosophila vesicular glutamate transporter DVGLUT and compares it to rat rVGLUT1, finding higher allosteric affinity and anion channel activity in flies.

This study investigates how Cl- binding modulates VGLUT1's protonation states, enhancing its glutamate transport and Cl- channel functions through allosteric effects.

The paper shows that glutamate transporters in ON-bipolar cells modulate inhibitory synaptic transmission in the vertebrate retina by affecting response kinetics and amplitude.

This study investigates the oligomerization and cellular localization of SLC26A11, finding it does not heterodimerize with other SLC26 proteins and remains localized to lysosomes.

This study elucidates the transport mechanism of DgoT, a bacterial homolog of SLC17 transporters, revealing key proton and substrate interactions that drive conformational changes and transport.