Shane R. Crandall

The paper investigates how presynaptic GABAergic signaling modulates top-down synaptic inputs in neocortical layer 1, revealing distinct effects on different interneuron subtypes and pathways.

The paper develops a biophysical model of the mouse thalamocortical circuit to show that closed-loop connectivity best reproduces thalamic activity during wakefulness and sleep.

The paper investigates how motor cortex inputs selectively influence distinct corticothalamic subcircuits in the somatosensory cortex, revealing differences in synaptic responses and intrinsic properties based on thalamic projection patterns.

The paper investigates two distinct synaptic pathways from motor cortex to layer 5 neurons in somatosensory cortex, showing different short-term dynamics and functional consequences.

The paper investigates the spiking patterns of layer 6 corticothalamic neurons in awake mice during whisking and locomotion, finding diverse response profiles linked to behavioral states.

The paper investigates short-term facilitation in long-range corticocortical synapses using optogenetic methods in mice, finding enhanced excitability and distinct synaptic properties across cell types.

This study assesses how TSC1 missense variants affect cortical inhibitory interneurons, revealing some variants can partially restore function while others show specific deficits.